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ULTRASTRUCTURE OF ISOLATED KIDNEY MITOCHONDRIA TREATED WITH PHLORIZIN AND ATP.
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MedLine Citation:
PMID:  14222809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Direct electron microscopic evidence is reported of the ultrastructure of mitochondrial membranes and compartments in mitochondria isolated in 0.5 M sucrose from the rat kidney cortex and the experimental changes they undergo with phlorizin and ATP treatment. A heterogeneous population of mitochondria is recognized under control conditions. The mitochondria appear to be of 3 main types, normal, swollen, and contracted. Under phlorizin treatment, most of the mitochondria swell in less than 15 minutes, apparently at the expense of the matrix. Treatment with ATP, on the other hand, produces, during the same time, a marked contraction of the isolated mitochondria, with many refoldings of the inner membrane and marked increase in the electron opacity of the matrix. It is concluded from these observations that mitochondrial swelling and contraction should be related mainly to the matrix content.
Authors:
M H BURGOS; A AOKI; F L SACERDOTE
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cell biology     Volume:  23     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1964 Nov 
Date Detail:
Created Date:  1965-03-01     Completed Date:  1996-12-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-15     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate*
Cell Biology*
Cytoplasm*
Densitometry*
Kidney*
Microscopy, Electron*
Mitochondria*
Pharmacology*
Phlorhizin*
Rats*
Research*
Sucrose*
Chemical
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 57-50-1/Sucrose; 60-81-1/Phlorhizin
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1964 by The Rockefeller Institute Press
Received Day: 13 Month: 11 Year: 1963
Print publication date: Day: 1 Month: 11 Year: 1964
Volume: 23 Issue: 2
First Page: 207 Last Page: 215
ID: 2106520
PubMed Id: 14222809

ULTRASTRUCTURE OF ISOLATED KIDNEY MITOCHONDRIA TREATED WITH PHLORIZIN AND ATP
Mario H. Burgos
Agustin Aoki
Fabio L. Sacerdote
From the Instituto de Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina


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