| Ultrastructure of human acute pancreatitis. | |
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MedLine Citation:
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PMID: 3693980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few studies have been published on the ultrastructural changes which accompany human acute pancreatitis, and these have concentrated primarily on parenchyma. The present study concentrates on extraparenchymal changes, compares acute pancreatitis occurring alone with that on a background of chronic pancreatitis, and tests for similarity with observations made previously in an experimental model. Pancreatic tissue came from 16 patients undergoing surgery for pancreatic disease and five subjects without pancreatic disease. Regressive changes in parenchymal cells were consistent with ischemia, and with previously described studies. Polymorphonuclear leukocytes infiltrated into stroma and parenchyma. Platelets accumulated intra- and extravascularly. Fibrin deposits were common in the connective tissue, and could be observed in intercellular spaces at the base of acini, mingled with degenerating acinar cells and secretion product. Microthrombi occurred in blood vessels. These alterations were consistent with those in experimental acute pancreatitis. Similar changes were observed whether or not acute pancreatitis occurred on a background of chronic pancreatitis. The vascular component is important in acute pancreatitis, and altered epithelial barriers allow interaction between blood-borne material and pancreatic exocrine secretions. |
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Authors:
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D E Bockman; M Büchler; H G Beger |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of pancreatology : official journal of the International Association of Pancreatology Volume: 1 ISSN: 0169-4197 ISO Abbreviation: Int. J. Pancreatol. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1988-01-26 Completed Date: 1988-01-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8703511 Medline TA: Int J Pancreatol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 141-53 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Medical College of Georgia, Augusta 30912. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Child Humans Middle Aged Pancreatitis / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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