Document Detail

Ultrastructure of the gingiva in cardiac patients treated with or without calcium channel blockers.
MedLine Citation:
PMID:  12887336     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In the last few years, several studies have suggested that periodontal diseases are related to the development of atherosclerosis and its complications. Our objective was to study the ultrastructural morphology of the gingiva from cardiac patients, some of whom were treated and some not with calcium channel blockers compared to a control group. MATERIAL AND METHODS: Fifty-five patients were studied and grouped in the following way: (a) healthy group (HG) (n=12) healthy patients with at least two pockets between 3 and 5 mm; (b) cardiac group (CG) (n=12) patients with cardiac disease untreated with calcium channel blockers; (c) diltiazem group (DG) (n=13) cardiac patients treated with diltiazem; (d) nifedipine group (NG) (n=18) cardiac patients treated with nifedipine. RESULTS: Ultrastructural studies in the CG showed inflammatory cells, collagen fibers disruption and a more extended morphologically compromised fibroblast mitochondria. Morphometric studies in CG showed mitochondria that were impaired in number but increased in volume, suggesting metabolic cell suffering. In DG and NG, morphometric data were similar to HG. The presence of myofibroblasts and collagen neosynthesis was detected in DG and NG. CONCLUSIONS: Our data showed differences in the ultrastructure of the gingival fibroblasts between the studied groups; the DG and NG showed features that could be interpreted as an attempt to restore the cellular metabolic function.
P Bullon; A Pugnaloni; I Gallardo; G Machuca; A Hevia; M Battino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  30     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2003-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  682-90     Citation Subset:  D; IM    
Department of Periodontology, Dental School, University of Sevilla, Sevilla, Spain.
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MeSH Terms
Calcium Channel Blockers / pharmacology*,  therapeutic use
Case-Control Studies
Diltiazem / pharmacology,  therapeutic use
Fibroblasts / drug effects,  pathology,  ultrastructure
Gingiva / cytology,  drug effects,  pathology*,  ultrastructure*
Gingival Overgrowth / chemically induced,  pathology
Heart Diseases / drug therapy,  pathology*
Hemidesmosomes / pathology,  ultrastructure
Mitochondria / drug effects,  metabolism,  pathology*,  ultrastructure
Mouth Mucosa / pathology,  ultrastructure
Nifedipine / pharmacology,  therapeutic use
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 42399-41-7/Diltiazem

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