| Ultrastructure of degenerating cerebellothalamic terminals in the ventral medial nucleus of the cat. | |
| | |
MedLine Citation:
|
PMID: 7188906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Terminal degeneration of cerebellar afferents in the ventral medial thalamic nucleus (VM) was studied in cats at the ultrastructural level after uni- or bilateral lesions in the brachium conjunctivum (BC). To achieve discrete lesions within the BC, a new very accurate stereotaxic technique was used. Numerous large terminals belonging to a population of so-called LR boutons were observed degenerating in the VM. The boutons displayed a wide variety of degenerative changes. Some revealed the features of the classical neurofilamentous type of degeneration. Others, although containing a slightly increased number of neurofilaments, featured much more prominently large numbers of coated vesicle shells and heavy accumulations of a flocculent electron-dense material. Degeneration in a third group of boutons similar to some extent to the light type of degeneration was characterized by tight clumping of enormously swollen or distorted synaptic vesicles within a light matrix. At later stages, however, all these boutons were believed to become shrunken and electron-dense since intermediate stages between the light- and dark-appearing boutons were observed. The degenerating cerebellar boutons formed asymmetrical synaptic contacts. Groups of 3 or 4 boutons terminated upon dendrites of projection neurons synapsing more frequently on spines than on dendritic stems. The synaptic contacts between cerebellar boutons and the vesicle-containing dendrites of local circuit neurons were encountered as often if not more than the contacts on projection neuron dendrites. Triads consisting of cerebellar boutons and dendrites of both types of neurons were observed very regularly. This synaptic arrangement provides the anatomical basis for the modification of cerebellar input in the VM by interneurons. |
| | |
Authors:
|
K Kultas-Ilinsky; I A Ilinsky; P A Young; K R Smith |
Related Documents
:
|
18703576 - Schwann cells modulate short-term plasticity of cholinergic autaptic synapses. 6341876 - Neural elements containing glutamic acid decarboxylase (gad) in the dorsal lateral geni... 3346386 - Differences in synaptic inputs to preganglionic neurons in the dorsal and lateral band ... 1677366 - An electron microscopic, immunogold analysis of glutamate and glutamine in terminals of... 2423166 - The role of mitochondria-rich cells in the chloride current conductance across toad skin. 8388636 - Isolation of plasma membrane fractions from the intestinal epithelial model t84. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale Volume: 38 ISSN: 0014-4819 ISO Abbreviation: Exp Brain Res Publication Date: 1980 Jan |
Date Detail:
|
Created Date: 1980-05-23 Completed Date: 1980-05-23 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0043312 Medline TA: Exp Brain Res Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 125-35 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Afferent Pathways
/
anatomy & histology Animals Axons / ultrastructure Cats Cerebellum / anatomy & histology* Cytoskeleton / ultrastructure Dendrites / ultrastructure Dominance, Cerebral / physiology Female Male Nerve Degeneration* Nerve Fibers / ultrastructure Nerve Fibers, Myelinated / ultrastructure Neuroglia / ultrastructure Synapses / ultrastructure Synaptic Vesicles / ultrastructure Thalamic Nuclei / anatomy & histology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Visualization of a filamentous network in cryo sections of liver tissue.
Next Document: Amaninamide, a new toxin of Amanita virosa mushrooms.