Document Detail

Ultrastructure changes of cardiac lymphatics during cardiac fibrosis in hypertensive rats.
MedLine Citation:
PMID:  19685503     Owner:  NLM     Status:  MEDLINE    
Hypertension is one of the most common diseases that induce a series of pathological changes in different organs of the human body, especially in the heart. There is a wealth of evidence about blood vessels in hypertensive myocardium, but little is known about structural changes in the cardiac lymphatic system. To clarify the changes in structure of the cardiac lymphatic system during hypertension, we developed a hypertension animal model with Dahl S rats and we used Dahl R rats as the control group. We examined the expression of collagen fibers, atrial natriuretic peptide, connexin43, and LYVE-1 in the rat heart by immunohistochemistry. The ultrastructure of the cardiac lymphatics was detected by transmission electron microscopy and scanning electron microscopy. We demonstrated extensive lymphatic fibrosis in the hearts of the Dahl S hypertension group, characterized by increased thin collagen fibrils that connected with the lymphatics directly. Ultrastructural changes in the cardiac lymphatic endothelium such as an increase of vesicles and occurrence of vacuoles, active exocytosis, and cytoplasmic processes, restored the draining of tissue fluid. Our study suggests that during hypertension, the changes in structure of the cardiac lymphatics may be one important factor involved in cardiac fibrosis. Therefore, the lymphatics may be a possible target for reducing fibrosis in the treatment of hypertension.
Xiaodong Li; Tatsuo Shimada; Yafang Zhang; Xianli Zhou; Linghui Zhao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  292     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-29     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1612-8     Citation Subset:  IM    
Department of Anatomy, Harbin Medical University, Harbin, China.
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MeSH Terms
Atrial Natriuretic Factor / metabolism
Connexin 43 / metabolism
Heart Atria / metabolism
Hypertension / pathology*
Lymphatic Vessels / ultrastructure*
Myocardium / metabolism,  ultrastructure*
Rats, Inbred Dahl
Reg. No./Substance:
0/Connexin 43; 85637-73-6/Atrial Natriuretic Factor

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