| Ultrastructure changes of cardiac lymphatics during cardiac fibrosis in hypertensive rats. | |
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MedLine Citation:
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PMID: 19685503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is one of the most common diseases that induce a series of pathological changes in different organs of the human body, especially in the heart. There is a wealth of evidence about blood vessels in hypertensive myocardium, but little is known about structural changes in the cardiac lymphatic system. To clarify the changes in structure of the cardiac lymphatic system during hypertension, we developed a hypertension animal model with Dahl S rats and we used Dahl R rats as the control group. We examined the expression of collagen fibers, atrial natriuretic peptide, connexin43, and LYVE-1 in the rat heart by immunohistochemistry. The ultrastructure of the cardiac lymphatics was detected by transmission electron microscopy and scanning electron microscopy. We demonstrated extensive lymphatic fibrosis in the hearts of the Dahl S hypertension group, characterized by increased thin collagen fibrils that connected with the lymphatics directly. Ultrastructural changes in the cardiac lymphatic endothelium such as an increase of vesicles and occurrence of vacuoles, active exocytosis, and cytoplasmic processes, restored the draining of tissue fluid. Our study suggests that during hypertension, the changes in structure of the cardiac lymphatics may be one important factor involved in cardiac fibrosis. Therefore, the lymphatics may be a possible target for reducing fibrosis in the treatment of hypertension. |
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Authors:
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Xiaodong Li; Tatsuo Shimada; Yafang Zhang; Xianli Zhou; Linghui Zhao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anatomical record (Hoboken, N.J. : 2007) Volume: 292 ISSN: 1932-8494 ISO Abbreviation: Anat Rec (Hoboken) Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101292775 Medline TA: Anat Rec (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 1612-8 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Harbin Medical University, Harbin, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / metabolism Connexin 43 / metabolism Fibrosis Heart Atria / metabolism Hypertension / pathology* Lymphatic Vessels / ultrastructure* Male Myocardium / metabolism, ultrastructure* Rats Rats, Inbred Dahl |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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