Document Detail

Ultrastructure of Fusarium-induced tibial dyschondroplasia in chickens: a sequential study.
MedLine Citation:
PMID:  2856859     Owner:  NLM     Status:  MEDLINE    
Female broiler chicks were randomly placed into two groups; one was treated twice daily with TDP-1 (a mycotoxin produced by Fusarium roseum), the other was controls. Chicks were sacrificed after 2, 4, 6, 8, 10, and 14 days of treatment and were evaluated for tibial dyschondroplasia. TDP-1-treated chicks examined after 2, 4, or 6 days of treatment had either no gross lesions (2 days) or mild gross lesions (4 and 6 days); growth plates from these groups did not have ultrastructural changes. TDP-1-treated chicks examined after 8, 10, or 12 days of treatment had moderate to severe gross lesions of tibial dyschondroplasia. These groups also had intracellular lipid accumulation and necrosis of chondrocytes within the retained cartilage. It was concluded that the cellular changes in tibial dyschondroplasia develop only after the cartilage accumulates; the changes are sequelae, possibly due to nutrient depletion from an increased distance between chondrocytes and perforating epiphyseal vessels, their nutrient source.
J S Haynes; M M Walser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary pathology     Volume:  23     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-10-01     Completed Date:  1986-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-505     Citation Subset:  IM    
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MeSH Terms
Amino Acids
Chickens / growth & development*
Growth Plate / ultrastructure*
Microscopy, Electron
Osteochondrodysplasias / chemically induced,  pathology,  veterinary*
Poultry Diseases / chemically induced,  pathology*
Tibia / ultrastructure*
Reg. No./Substance:
0/Amino Acids; 0/Chromones; 0/Mycotoxins; 104653-89-6/fusarochromanone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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