Document Detail

Ultrastructural study of tumor cell differentiation in osteosarcoma of jaw bones.
MedLine Citation:
PMID:  96236     Owner:  NLM     Status:  MEDLINE    
Tw osteosarcomas of jaw bones have been studied by electron microscopy. The objectives were to examine the specific cell types in relation to functions and ultrastructural features, and to examine matrices produced by tumor cells. The osteosarcoma cells were subdivided into four cell types: anaplastic, chondroblastic, osteoblastic, and osteocytic--giant cells were not considered in the present investigation. Compared to normal bone cells, no specific sign of malignancy was found. However, tumor cells seem to lose functional abilities, i.e. a modification of matrix. Consequently, tumor matrix has altered organic and inorganic components with impairment of collagen maturation and matrix mineralization. The alteration in both processes may be related to a diminished production of proteoglycans. The cytogenic hypothesis of a tumor stem cell may be supported by the identification of anaplastic osteosarcoma cells resembling immature reticulum cells. One may speculate on transformation of this cell type as a genetically predetermined osteoprogenitor cell of malignant potential.
A Schulz; R Baerker; G Delling
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of oral pathology     Volume:  7     ISSN:  0300-9777     ISO Abbreviation:  J. Oral Pathol.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0342050     Medline TA:  J Oral Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  69-84     Citation Subset:  D; IM    
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MeSH Terms
Cell Membrane / ultrastructure
Cell Transformation, Neoplastic
Cytoplasm / ultrastructure
Desmosomes / ultrastructure
Endoplasmic Reticulum / ultrastructure
Mandibular Neoplasms / radiography,  ultrastructure*
Middle Aged
Mitochondria / ultrastructure
Osteosarcoma / radiography,  ultrastructure*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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