Document Detail

Ultrastructural study of the local changes induced in the white rat by the venom of Bothrops picadoi of Costa Rica
MedLine Citation:
PMID:  6729845     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of local lesions induced by Bothrops picadoi venom was studied at the electron microscopic level. White mice were injected i.m. with 100 micrograms of venom. A strong hemorrhagic action was the earliest and most prominent local effect observed in this study. In skeletal muscle fibers, rupture of the sarcolemma was observed and myofibril structure was drastically affected, showing amorphous masses of myofilaments. Myelin layers in many axons were disorganized.
O Arroyo; L Cerdas
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  22     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1984  
Date Detail:
Created Date:  1984-07-02     Completed Date:  1984-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  spa     Pagination:  301-5     Citation Subset:  IM    
Vernacular Title:
Estudio ultraestructural de las alteraciones locales inducidas en ration blanco por el veneno de Bothrops picadoi de Costa Rica.
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MeSH Terms
Axons / ultrastructure
Crotalid Venoms / toxicity*
Hemorrhage / pathology
Neurons / ultrastructure
Skin / pathology
Snake Bites / pathology*
Reg. No./Substance:
0/Crotalid Venoms

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