| Ultrastructural study of the infection process of Rickettsia conorii in the salivary glands of the vector tick Rhipicephalus sanguineus. | |
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MedLine Citation:
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PMID: 12737546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work was designed to study the infection process of Rickettsia conorii in the salivary glands of experimentally infected Rhipicephalus sanguineus ticks. One hundred six uninfected engorged nymphs were intracelomically inoculated with approximately 2 x 10(3) plaque-forming units of a rickettsial suspension. After the molt, unfed and fed adults were dissected, and the salivary glands were extracted and processed for transmission electron microscopy observation. Three different uninfected control groups were used for (1) evaluating the impact of the inoculation procedure, (2) establishing the feeding period of infected ticks, and (3) ultrastructural characterization of the salivary glands. Overall, 75.5% (80 of 106) of the nymphs inoculated with rickettsiae died during the molt or soon after hatching into adult instars; 50% (12 of 24) of the remaining infected adults showed severe malformations compromising their viability. In apparently healthy specimens, time of engorgement was longer. The contrast with the negative control groups was statistically significant, suggesting that R. conorii exerts a strong negative effect on the vector ticks. The ultrastructural study showed that in the salivary glands of infected ticks, rickettsial growth occurs preferentially in central, peripheral, and interstitial acini cells. |
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Authors:
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A S Santos; F Bacellar; M Santos-Silva; P Formosinho; A J Grácio; S Franca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Vector borne and zoonotic diseases (Larchmont, N.Y.) Volume: 2 ISSN: 1530-3667 ISO Abbreviation: Vector Borne Zoonotic Dis. Publication Date: 2002 |
Date Detail:
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Created Date: 2003-05-09 Completed Date: 2003-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100965525 Medline TA: Vector Borne Zoonotic Dis Country: United States |
Other Details:
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Languages: eng Pagination: 165-77 Citation Subset: IM |
Affiliation:
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Centro de Estudos de Vectores e Doenças Infecciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Aguas de Moura, Portugal. ana.santos@insa.min-saude.pt |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachnid Vectors / microbiology*, ultrastructure* Molting Rickettsia conorii / physiology*, ultrastructure Salivary Glands / microbiology*, ultrastructure* Ticks / microbiology*, ultrastructure* |
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