Document Detail

Ultrastructural study of acute lymphocytic leukemia: comparison with immunologic studies.
MedLine Citation:
PMID:  307416     Owner:  NLM     Status:  MEDLINE    
Leukemic cells from 29 cases of acute lymphocytic leukemia (ALL), studied for T and B cell markers by the use of sheep erythrocyte rosetting and surface immunoglobulin determinations, were examined by electron microscopy. The majority of patients (76%) were found to have non-T, non-B neoplasms composed predominantly of relatively small, inactive-appearing cells with frequent nuclear folds. T cell cases (21%) were associated with mediastinal masses and were predominantly composed of large, active-appearing cells with nuclear irregularity and little rough endoplasmic reticulum. One case of B cell origin was not morphologically distinct from the non-T, non-B cell cases.
A D Glick; B K Vestal; J M Flexner; R D Collins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  52     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-09-29     Completed Date:  1978-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-22     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes / ultrastructure
Cell Nucleus / ultrastructure
Child, Preschool
Endoplasmic Reticulum / ultrastructure
Leukemia, Lymphoid / immunology,  ultrastructure*
Middle Aged
Polyribosomes / ultrastructure
Rosette Formation
T-Lymphocytes / ultrastructure

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