Document Detail


Ultrastructural studies of subependymal extracellular spaces in adult and neonatal rat brain.
MedLine Citation:
PMID:  6161907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrastructural studies of the subependymal neuropil of the lateral ventricular wall in the adult rat reveal two different types of enlarged extracellular spaces which appear to be due to the presence of glycosaminoglycans. Focal irregular enlargements are more numerous and are distinguished by the presence of fibrillar material. The other network is characterized by uniform width, branching processes, and an electron density identical to vascular basement membranes. The origin of the extracellular material is not revealed by these studies, but a relationship is suggested between the focal dilatation and subependymal cells. The distinction of these spaces is emphasized by the study of neonatal brain and by the use of ruthenium red (RR). Focal dilatations are very prominent in the 10 day old rat, but they do not contain fibrillar material. An adult type basement membrane-like network is present at this time. In the adult rat the focal dilatation has great affinity for RR, but the second network is very sparsely stained. The RR affinity is not present in the 10 day old rat; however, by the 26th day, the affinity is almost as great as that of an adult. These findings are considered to enhance the concept of a separate origin, composition, and probable function of these two networks.
Authors:
R M Torack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histochemistry     Volume:  68     ISSN:  0301-5564     ISO Abbreviation:  Histochemistry     Publication Date:  1980  
Date Detail:
Created Date:  1981-04-13     Completed Date:  1981-04-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0411300     Medline TA:  Histochemistry     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  297-307     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / anatomy & histology*
Ependyma / ultrastructure*
Extracellular Space / analysis*
Male
Microscopy, Electron
Rats
Ruthenium Red
Staining and Labeling
Chemical
Reg. No./Substance:
11103-72-3/Ruthenium Red

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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