Document Detail

Ultrastructural observations of intermediate cells in chronic pancreatitis.
MedLine Citation:
PMID:  12143217     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The intermediate cells exhibiting both exo- and endocrine features occur in small numbers in the normal and pathologic pancreas of many animal species. In human pathology their presence has been reported in children with hyperinsulinemia, in hypoglycemia, and chronic hypergastrinemia. METHODOLOGY: Fragments of the pancreas collected from 27 patients operated on for chronic pancreatitis of various intensity fibrosis (I degree-IV degree) was subjected to ultrastructural analysis. RESULTS: All chronic pancreatitis cases revealed the presence of intermediate cells that were found outside Langerhans islets, separately or in small groups. They were more common in III degree and IV degree chronic pancreatitis. All forms of chronic pancreatitis with I degree-IV degree fibrosis showed, apart from undamaged cells, numerous intermediate cells with features of destruction. Some intermediate cells contained fibrillate cytoplasm inclusion bodies. Intermediate cells took part in the formation of acini and were also found among ductural cells. CONCLUSIONS: The presence of intermediate cells both within the acinar texture and among proliferating ductular cells confirms the common origin of these cellular elements of the pancreas. In chronic pancreatitis intermediate cells appear during pancreatic texture regeneration, being rather abnormal cell forms produced in this process than an intermediate stage in precursor cell differentiation.
Beata Szynaka; Lech Zimnoch; Zbigniew Puchalski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  49     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-07-29     Completed Date:  2003-02-13     Revised Date:  2006-12-07    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1120-3     Citation Subset:  IM    
Department of Pathological Anatomy, Medical Academy of Bialystok, Poland.
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MeSH Terms
Chronic Disease
Cytoplasmic Granules / pathology
Inclusion Bodies / ultrastructure
Microscopy, Electron
Pancreas / pathology*
Pancreatitis / pathology*

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