Document Detail

Ultrastructural, morphometric, and hormonal analysis of the effects of testosterone treatment on Leydig cells and other interstitial cells in young adult rats.
MedLine Citation:
PMID:  11677807     Owner:  NLM     Status:  MEDLINE    
Early effects of testosterone (T) treatment on the ultrastructure of testicular interstitium were analyzed by morphometry. In T-treated young adult rats the T-LH feed-back loop functioned as expected and the marked increase in peripheral T caused almost complete depletion of peripheral LH. Even though the peripheral LH concentration was almost undetectably low, the Leydig cells maintained regulatory interactions with macrophages, peritubular myoid cells and with the seminiferous epithelium lining the tubular lumina as indicated by the high correlations of morphometric parameters between the Leydig and other cell types. The morphometric alterations in the ultrastructure of Leydig cells suggest that the seminiferous tubules may signal by releasing inhibitory paracrine factors affecting the morphology and function of Leydig cells in T-treated young adult rats. The morphometry of Leydig cells in T-treated young adult rats showed a significant quantifiable reduction in nuclei and organelles involved in steroid synthesis and this analysis also offers a good basis for elucidation of the early effects of testosterone in terms of its contraceptive function as well as of different toxic compounds on reproductive functions.
I Ichihara; H Kawamura; T Nakano; L J Pelliniemi
Related Documents :
1322317 - Immortalization of germ cells and somatic testicular cells using the sv40 large t antigen.
8837997 - Vitronectin in the cytoplasm of leydig cells in the rat testis.
9389487 - Developmental changes in glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenas...
6465527 - Ultrastructure of immature leydig cells in the human prepubertal testis.
1530637 - Vitamin k2 modulates proliferation and function of osteoblastic cells in vitro.
16950797 - Hsp70 protects against uvb induced apoptosis by preventing release of cathepsins and cy...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft     Volume:  183     ISSN:  0940-9602     ISO Abbreviation:  Ann. Anat.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-25     Completed Date:  2002-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  100963897     Medline TA:  Ann Anat     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  413-26     Citation Subset:  IM    
Department of Anatomy, Aichi Medical University, Yazako, Nagakute-cho, Aichi-ken, 480-1195 Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Leydig Cells / drug effects*,  ultrastructure
Microscopy, Electron / methods
Rats, Wistar
Testis / cytology,  drug effects,  ultrastructure
Testosterone / blood,  pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  N- and R-cadherins expression in the rat sciatic nerve demonstrated by postembedding immunogold meth...
Next Document:  Ultrastructure of the epithelial cells in the aspermatogenic part of the testis in Mimagoniates barb...