Document Detail

Ultrastructural morphometric examinations on the protection provided by prostacyclin against myocardial ischaemia.
MedLine Citation:
PMID:  3891396     Owner:  NLM     Status:  MEDLINE    
Myocardial ischaemia in the dog lasting for three hours is followed by swellings of the mitochondria and dilatation of the sarcoplasmic reticulum. The volume density (Vv) of mitochondria in the peripheral ischaemia zone is 0.2890, that of sarcoplasmic reticulum is 0.0101. Prostacyclin was administered either i.v. or by triggering in conjunction with an intra-aortic balloon pump which led to an increase in the volume density of the mitochondria, mainly as a result of an increase in the volume of average mitochondria. The dilatation of the sarcoplasmic reticulum is reversed. It was not possible to prove in our investigations that prostacyclin provides protection against myocardial ischaemia.
H David; H Goos; J Nöhring; K F Lindenau; D Behrisch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental pathology     Volume:  27     ISSN:  0232-1513     ISO Abbreviation:  Exp Pathol     Publication Date:  1985  
Date Detail:
Created Date:  1985-08-12     Completed Date:  1985-08-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8108218     Medline TA:  Exp Pathol     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / metabolism,  pathology,  prevention & control*
Epoprostenol / therapeutic use*
Lipid Metabolism
Lipofuscin / metabolism
Microscopy, Electron
Mitochondria, Heart / pathology,  ultrastructure
Mitochondrial Swelling / drug effects
Reg. No./Substance:
0/Lipofuscin; 35121-78-9/Epoprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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