Document Detail

Ultrastructural modifications at uterine cervix level induced by human papillomaviruses infections.
MedLine Citation:
PMID:  11845447     Owner:  NLM     Status:  MEDLINE    
The paper presents the ultrastructural modifications occurring in uterine cervix epithelium in 10 patients with clinical susceptibility of HPV infections. The presence of viral HPV particles was identified in 5 cases and in 1 case the concomitant presence of both HPV and HSV2 particles was detected. The maximum amount of HPV virions is found in the spinous and superficial layer, particularly in the nucleus, but also in cytoplasm. In all the studied cases, cellular alterations were present in the whole depth of the epithelium. The degree of cellular alterations depends upon the epithelial layer to which they belong and to the stage of the disease as well. Cellular alterations are more pronounced at the level of the spinous and superficial layer being present both in nucleus (chromatin condensations, invaginations of the nuclear membrane, the occurrence of some pseudonuclei) and cytoplasm (intracytoplasmic vacuolizations, the presence of some inclusions). The presence of some giant mono- and binucleated cells as well as the formation of cellular syncytia in case of severe alterations are also reported.
N Coman; M D Ionescu; D Mişcalencu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Roumanian archives of microbiology and immunology     Volume:  58     ISSN:  1222-3891     ISO Abbreviation:  Roum Arch Microbiol Immunol     Publication Date:    1999 Jan-Mar
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204717     Medline TA:  Roum Arch Microbiol Immunol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  65-78     Citation Subset:  IM    
Cantacuzino Institute, Bucharest, Romania.
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MeSH Terms
Cervix Uteri / ultrastructure*,  virology
Epithelium / ultrastructure,  virology
Giant Cells / ultrastructure
Herpesvirus 2, Human
Inclusion Bodies
Microscopy, Electron
Neutrophils / ultrastructure
Papillomavirus Infections / pathology*,  virology
Tumor Virus Infections / pathology*,  virology
Uterine Cervical Diseases / pathology*,  virology

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