Document Detail

Ultrastructural localization of cisplatin in Ehrlich ascites tumor cells.
MedLine Citation:
PMID:  3359413     Owner:  NLM     Status:  MEDLINE    
The incorporation of cis-diammine Dichloro Platinum (II) (cisplatin) on the Ehrlich ascites carcinoma (EAT) cells has been studied in this paper. Ultrastructural study of cells treated 'in vivo' with cisplatin showed that a new treatment with this substance after fixation, blocks uranyl acetate staining with the consequent lack of heterochromatin contrast.
V Rodilla; J Pertusa; J A Pellicer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  39     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-02     Completed Date:  1988-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  179-83     Citation Subset:  IM    
Department of Animal Biology, University of Valencia, Spain.
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MeSH Terms
Carcinoma, Ehrlich Tumor / analysis*,  ultrastructure
Cell Nucleus / analysis
Cisplatin / analysis*
DNA / analysis
Organometallic Compounds / diagnostic use
Tissue Distribution
Reg. No./Substance:
0/Organometallic Compounds; 15663-27-1/Cisplatin; 541-09-3/uranyl acetate; 9007-49-2/DNA

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