Document Detail

Ultrastructural localization of Brazilian pemphigus foliaceus (fogo selvagem) antigens in cultured human squamous cell carcinoma cells.
MedLine Citation:
PMID:  7684244     Owner:  NLM     Status:  MEDLINE    
The ultrastructural localization of Brazilian pemphigus foliaceus (BPF) (fogo selvagem) antigen(s) in cultured human squamous cell carcinoma cells was studied using immunogold electron microscopy. Five of six BPF sera, which showed positive cell-surface reactivity on immunofluorescence, bound to the cell-cell contact area of cytoplasmic projections. This binding pattern was apparently different from that of non-endemic pemphigus foliaceus and pemphigus vulgaris sera, and mouse monoclonal anti-human E-cadherin antibody. The results suggest that BPF autoantibodies recognize a molecule(s) which is different from non-endemic pemphigus antigens, or different epitope(s) of a molecule identical with non-endemic pemphigus antigens, and that the epitope(s) to which BPF autoantibodies bind is expressed on cell-cell contact areas at a relatively early stage of cell-cell adhesion formation.
M Akiyama; T Hashimoto; M Sugiura; T Nishikawa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  128     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-24     Completed Date:  1993-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  378-83     Citation Subset:  IM    
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Autoantigens / analysis*
Binding Sites, Antibody
Carcinoma, Squamous Cell / immunology*,  ultrastructure
Cell Adhesion Molecules / analysis
Epitopes / analysis
Microscopy, Electron
Pemphigus / immunology*
Penile Neoplasms / immunology
Tumor Cells, Cultured / immunology
Reg. No./Substance:
0/Autoantigens; 0/Binding Sites, Antibody; 0/Cell Adhesion Molecules; 0/Epitopes

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