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Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury.
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MedLine Citation:
PMID:  805209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During blood coagulation ultrastructural lesions were produced on the platelet membrane. They were dependent on the presence of both thrombin and complement (C) and were morphologically identical to the C-dependent ultrastructural lesions (type II) seen in red cells subsequent to activation of C by the alternate mechanismmthough similar in shape they differed in size from ultrastructural lesions (type I) PRODUCED BY ACTIVATION OF C via the classic mechanismmlesions of type I were seen on the platelet surface subsequent to antibody-dependent activation of the C system.
Authors:
M J Polley; R L Nachman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  141     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-08-04     Completed Date:  1975-08-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1261-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aluminum Hydroxide
Binding Sites, Antibody*
Blood Coagulation*
Blood Platelets / ultrastructure*
Calcium / pharmacology
Complement C3 / pharmacology
Complement Fixation Tests
Complement System Proteins*
Edetic Acid / pharmacology
Humans
Magnesium / pharmacology
Microscopy, Electron
Thrombin / pharmacology
Chemical
Reg. No./Substance:
0/Binding Sites, Antibody; 0/Complement C3; 21645-51-2/Aluminum Hydroxide; 60-00-4/Edetic Acid; 7439-95-4/Magnesium; 7440-70-2/Calcium; 9007-36-7/Complement System Proteins; EC 3.4.21.5/Thrombin
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 6 Year: 1975
Volume: 141 Issue: 6
First Page: 1261 Last Page: 1268
ID: 2189843
Publisher Id: 75152678
PubMed Id: 805209

Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury


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