| Ultrastructural and kinetic studies of copper metabolism in Bedlington Terrier dogs. | |
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MedLine Citation:
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PMID: 12450209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objectives of this study were to determine the time course of copper (Cu) absorption in the Bedlington Terrier (BT) dog after duodenal infusion of Cu and to determine the onset of Cu accumulation in BT puppies. At 80 minutes after infusion, Cu was present in the bile and liver at 26.1 and 2675 microg/g dry weight (dw), as compared with 598 and 224 microg/g dw, respectively, in the control. In the puppies, the mean liver Cu concentrations were 443 +/- 216 microng/g dw as compared with 54 +/- 34 microg/g dw in their controls. The BT puppies had large numbers of Cu granules in their hepatic lysosomes, with very few in the bile canaliculi. In contrast, the controls had few granules in their lysosomes and large numbers in their canaliculi. These results suggest that hepatic Cu accumulation occurs rapidly and in utero in the BT. |
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Authors:
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M Kawamura; I Takahashi; J J Kaneko |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary pathology Volume: 39 ISSN: 0300-9858 ISO Abbreviation: Vet. Pathol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-02-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 747-50 Citation Subset: IM |
Affiliation:
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Kawamura Animal Hospital, Tokyo, Japan. kah115@blue.ocn.ne.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Bile Canaliculi / chemistry, metabolism*, pathology Biopsy / veterinary Copper / blood, metabolism, pharmacokinetics* Dog Diseases / metabolism*, pathology Dogs Female Histocytochemistry / veterinary Liver / metabolism*, pathology, ultrastructure Male Microscopy, Electron / veterinary Pregnancy |
| Chemical | |
Reg. No./Substance:
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7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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