Document Detail

Ultrastructural investigation of renomedullary interstitial cells in "endocrine kidney".
MedLine Citation:
PMID:  7471759     Owner:  NLM     Status:  MEDLINE    
In the renomedullary interstitial cells of rats with Selye's "endocrine kidney" in the phase of beginning hypertension there appeared bilateral stress hypergranulation and an ultrastructural pattern of intensive prostaglandin synthesis. In the interstitial tissue of the left medulla there appeared light and dense (fibroblast- or macrophage-like) cells. Along with the stabilization of hypertension a relative degranulation of interstitial cells in the right kidney and an absolute degranulation in the left kidney took place. Necrobiotic changes, appearing in the ischaemic kidney, reflected an exhaustion of morphological substrates of prostaglandin synthesis. The changes in the interstitial cells, possessing endocrine activity, present the decisive links in the genesis of experimental malignant hypertension in rats.
B L Anavi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  22     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1980  
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  445-54     Citation Subset:  IM    
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MeSH Terms
Aorta / pathology
Aortic Diseases / pathology
Constriction, Pathologic
Hypertension, Renal / pathology*
Hypertension, Renovascular / pathology*
Kidney / blood supply
Kidney Medulla / ultrastructure*

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