Document Detail

Ultrastructural immunochemistry of J chains in chickens.
MedLine Citation:
PMID:  2113336     Owner:  NLM     Status:  MEDLINE    
Using ultrastructural immunochemistry, we have determined subcellular localization of J chain molecules in chicken splenic cells. The majority of J chain positive cells (JPC) were lymphoblast-like cells. The data show that J chains predominantly are localized in cytoplasm with a considerable amount distributed on the cell surface. In the cytoplasm, J chains were diffusely expressed. Furthermore, these J chain molecules were clearly seen as cluster type. In addition to the J chain localization of subcellular organelles as described above, J chains were partly found on perinuclear spaces. As J chains are key protein in B cell differentiation into immunoglobulin (Ig) producing cells, these findings might help for studying regulation of B cell differentiation in addition to revealing the molecular assembly of polymeric Ig.
O Moriya; Y Ichikawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta histochemica     Volume:  88     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-24     Completed Date:  1990-07-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  IM    
Department of Bacteriology, Saitama Medical School, Japan.
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MeSH Terms
Cell Membrane / immunology,  ultrastructure
Immune Sera
Immunoenzyme Techniques
Immunoglobulin J-Chains / analysis*
Lymphocytes / immunology*,  ultrastructure
Microscopy, Electron
Spleen / immunology*,  ultrastructure
Reg. No./Substance:
0/Immune Sera; 0/Immunoglobulin J-Chains

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