Document Detail


Ultrastructural identification of cells with dendritic cell appearance in atherosclerotic aorta of apolipoprotein E deficient mice.
MedLine Citation:
PMID:  10685393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present electron microscopic study was undertaken to see whether cells with a dendritic cell appearance accumulate in atherosclerotic lesions of apolipoprotein E (apoE) deficient mice. Atherosclerotic aortas from 7 eight-month old apoE deficient mice were examined. In atherosclerotic plaques as well as in the underlying media and adventitia, cells with a dendritic cell appearance including the presence of a unique tubulovesicular system were detected. The tubulovesicular system was most hypertrophied in their cellular processes where the continuous cisterns sometimes formed circular structures. The cells containing the tubulovesicular system lacked lysosomes and phagolysosomes and their cytoplasm was free of lipid inclusions. The present observations suggest that dendritic cells are involved in apoE deficient mouse atherosclerosis. ApoE deficient mice might be a useful model for investigating functions of dendritic cells in atherogenesis.
Authors:
Y V Bobryshev; V R Babaev; R S Lord; T Watanabe
Related Documents :
9164923 - Ctla4ig prevents lymphoproliferation and fatal multiorgan tissue destruction in ctla-4-...
10068903 - Immunohistochemical localization of bioactive substances in the epidermis of the earthw...
6969523 - Hepatic fibrosis. the relation between proliferating bile ductules and alpha1-antitrypsin.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of submicroscopic cytology and pathology     Volume:  31     ISSN:  1122-9497     ISO Abbreviation:  J. Submicrosc. Cytol. Pathol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-03-20     Completed Date:  2000-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804312     Medline TA:  J Submicrosc Cytol Pathol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  527-31     Citation Subset:  IM    
Affiliation:
Surgical Professorial Unit, St. Vincent's Hospital, Darlinghurst, NSW, Australia. ybobryshev@stvincents.com.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / pathology*
Apolipoproteins E / deficiency*,  genetics
Arteriosclerosis / etiology,  genetics,  pathology*
Dendritic Cells / ultrastructure*
Lysosomes / ultrastructure
Mice
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Electron
Phagosomes / ultrastructure
Chemical
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lymphatic vessels of the human heart: precollectors and collecting vessels. A morpho-structural stud...
Next Document:  Cytotoxic effects of eosinophils on renal proximal tubular epithelial cells: implications for renal ...