| Ultrastructural identification of cells with dendritic cell appearance in atherosclerotic aorta of apolipoprotein E deficient mice. | |
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MedLine Citation:
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PMID: 10685393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present electron microscopic study was undertaken to see whether cells with a dendritic cell appearance accumulate in atherosclerotic lesions of apolipoprotein E (apoE) deficient mice. Atherosclerotic aortas from 7 eight-month old apoE deficient mice were examined. In atherosclerotic plaques as well as in the underlying media and adventitia, cells with a dendritic cell appearance including the presence of a unique tubulovesicular system were detected. The tubulovesicular system was most hypertrophied in their cellular processes where the continuous cisterns sometimes formed circular structures. The cells containing the tubulovesicular system lacked lysosomes and phagolysosomes and their cytoplasm was free of lipid inclusions. The present observations suggest that dendritic cells are involved in apoE deficient mouse atherosclerosis. ApoE deficient mice might be a useful model for investigating functions of dendritic cells in atherogenesis. |
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Authors:
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Y V Bobryshev; V R Babaev; R S Lord; T Watanabe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of submicroscopic cytology and pathology Volume: 31 ISSN: 1122-9497 ISO Abbreviation: J. Submicrosc. Cytol. Pathol. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-03-20 Completed Date: 2000-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804312 Medline TA: J Submicrosc Cytol Pathol Country: ITALY |
Other Details:
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Languages: eng Pagination: 527-31 Citation Subset: IM |
Affiliation:
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Surgical Professorial Unit, St. Vincent's Hospital, Darlinghurst, NSW, Australia. ybobryshev@stvincents.com.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / pathology* Apolipoproteins E / deficiency*, genetics Arteriosclerosis / etiology, genetics, pathology* Dendritic Cells / ultrastructure* Lysosomes / ultrastructure Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Phagosomes / ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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