| Ultrastructural heterogeneity of epithelioid cells in cutaneous organized granulomas of diverse etiology. | |
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MedLine Citation:
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PMID: 2036027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In organized granulomatous inflammation, activated macrophages terminally differentiate into epithelioid cells (ECs). By light microscopy, individual ECs appear similar, irrespective of the inciting agent. Ultrastructural analysis of a number of clinical and experimental granulomas in man and mice reveals, however, three distinct varieties of these cells. They are classified as follows: (1) EC-I cells containing a mixture of lysosomal-dense bodies and phagolysosomes and arrays of rough endoplasmic reticulum in the cytoplasm; (2) EC-II cells showing primarily a secretory mode with prominent Golgi bodies and rich arrangement of dilated rough endoplasmic reticulum with no phagocytic vacuoles; and (3) EC-III cells containing large multisized vesicles crowded throughout the cytoplasm and presently of unknown function. Although the unique appearance of these cells offers little diagnostic help, the cells do distribute differentially in different granulomas. The EC-I cells tend to predominate in infectious granulomas and where an excess of foreign material and debris is present. The EC-II cells are most characteristic of active sarcoidal granulomas, and the EC-III cells appear in chronic, long-standing granulomas. The heterogeneic nature of these cells seems to suggest their functions in granulomatous inflammation are not always the same. |
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Authors:
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W L Epstein |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of dermatology Volume: 127 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-06-27 Completed Date: 1991-06-27 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 821-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, University of California, San Francisco 94143. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Epithelioid Cells
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ultrastructure* Granuloma / pathology* Humans Microscopy, Electron Skin Diseases / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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AR31853/AR/NIAMS NIH HHS |
| Comments/Corrections | |
Comment In:
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Arch Dermatol. 1991 Jun;127(6):871-84
[PMID:
2036036
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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