Document Detail


Ultrastructural evidence for eosinophil-mediated destruction of Angiostrongylus cantonensis transferred into the pulmonary artery of non-permissive hosts.
MedLine Citation:
PMID:  6718049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrastructural and cytochemical analyses were carried out on cellular reactions to the young adult worms of Angiostrongylus cantonensis surgically transferred into the pulmonary arteries of permissive (rat) and non-permissive (rabbit and guinea-pig) hosts. In permissive hosts, no appreciable cellular reactions could be found around worms throughout the course of the observations. By contrast, the infiltration of neutrophils along with eosinophils was observed around worms in non-permissive hosts even at early stages (days 2 to 4). At day 7 and later, the prominent degranulation (solubilization of the whole granule or the matrix alone with preserved crystalloid, tubulovesicular structure formation, and vacuole formation containing lysosomal contents, etc.) of eosinophils, and subsequent release of the lysosomal contents on to the worm surface were noted. Discharge of large amounts of peroxidase on to the worm surface was also demonstrated. The worms were thus damaged and their cuticular fragments were frequently found removed. In addition to this, degenerative changes, such as lipid-droplet and vacuole formations, were detectable in the hypodermis, somatic musculature and intestine of the parasites transferred into the non-permissive hosts, as early as day 4 after transfer. These data suggest that eosinophils would serve as a potential effector cell for killing of pulmonary arterial A. cantonensis in non-permissive hosts.
Authors:
K Yoshimura; K Uchida; K Sato; H Oya
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite immunology     Volume:  6     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-06-01     Completed Date:  1984-06-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  105-18     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiostrongylus / pathogenicity*,  ultrastructure
Animals
Disease Susceptibility
Eosinophils / immunology*,  ultrastructure
Guinea Pigs
Immunity, Innate
Male
Metastrongyloidea / pathogenicity*
Microscopy, Electron
Nematode Infections / immunology*,  pathology
Pulmonary Artery / ultrastructure*
Rabbits
Rats
Rats, Inbred Strains
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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