Document Detail


Ultrastructural evidence for direct monosynaptic rubrospinal connections to motoneurons in Macaca mulatta.
MedLine Citation:
PMID:  2465507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The magnocellularis division of the red nucleus of the Macaca mulatta, a midbrain structure involved in processing motor information, is known by light microscopic analysis to project, via the rubrospinal tract, to the contralateral intermediate horn of the spinal cord. Physiological studies, however, provide additional evidence for direct monosynaptic connections to motoneurons subserving distal musculature. This electron microscopic study demonstrates, by analyzing the anterograde transport of 5% wheatgerm agglutinin-horseradish peroxidase injected into the red nucleus, the presence of labeled terminals synapsing upon somata and proximal dendrites of motoneurons in the lateral portion of the ventral horn of the cervical enlargement of the spinal cord. We conclude that this anatomical evidence confirms the presence of direct monosynaptic connections to spinal motoneurons in the primate.
Authors:
D D Ralston; A M Milroy; G Holstege
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  95     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Affiliation:
Department of Anatomy, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Animals
Efferent Pathways / anatomy & histology,  physiology
Horseradish Peroxidase / diagnostic use
Macaca / anatomy & histology*
Macaca mulatta / anatomy & histology*
Microscopy, Electron
Motor Neurons / physiology,  ultrastructure*
Red Nucleus / anatomy & histology*,  physiology,  ultrastructure
Reflex, Monosynaptic*
Spinal Cord / anatomy & histology*,  physiology,  ultrastructure
Synapses / ultrastructure*
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Wheat Germ Agglutinins / diagnostic use
Grant Support
ID/Acronym/Agency:
NS 23347/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; 0/Wheat Germ Agglutinins; EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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