Document Detail


Ultrastructural differences of hippocampal lipofuscin in human development.
MedLine Citation:
PMID:  7791404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lipofuscin of pyramidal cells in each hippocampal subfield of each of seven human autopsy cases without brain disease at the age of 3-12 months (infants) and of 17-23 years (young adults) was comparatively investigated at the electron microscopic level. In infant pyramidal neurons of the hippocampal subfields CA 1, CA 2, CA 3 and CA 4 O-2, very small lipofuscin particles were observed. The lipofuscin composition showed a slightly larger granular component compared to the vacuolar component with one or two small lipid droplets. No obvious ultrastructural variability of lipofuscin granules was observed. The CA 1 lipofuscin in young adults consists of larger particles than in infants, but no obvious difference in the composition of granular and vacuolar components from the infant lipofuscin was seen. The amount of lipofuscin in CA 1 strongly increased in young adults compared to infants and appeared in a perinuclear distribution. In young adults, in contrast to the infant group, the amount of lipofuscin in the subfields CA 2, CA 3 and CA 4 was significantly higher than in CA 1. In CA 2, CA 3 and CA 4 pyramidal neurons, the vacuolar component was significantly larger than the granular component. The similarity of infant hippocampal lipofuscin patterns in all subfields is discussed as a state of immaturity. To explain the observed differences between the CA 1 and the other subfields during neuronal development, as shown in the young adult group, several factors are discussed: the effects of cell specific metabolism, cellular functional activity, cytoprotective mechanisms and effects of efferent and afferent pathways connected with the subfields.
Authors:
D R Thal; W Schlote
Related Documents :
11740894 - The first in vivo observation of (13)c-(15)n coupling in mammalian brain.
9485064 - Quantitative magnetic resonance imaging of brain development in premature and mature ne...
20569814 - Ureaplasma species: role in diseases of prematurity.
15313724 - Posterior fontanelle sonography: an acoustic window into the neonatal brain.
12191434 - Key-factor analysis of immature stages of aedes scapularis (diptera: culicidae) populat...
7724304 - Neonatal pulmonary mechanics and oxygenation after prophylactic amnioinfusion in labor:...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  79     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  59-70     Citation Subset:  IM    
Affiliation:
Department of Neuropathology, University of Frankfurt, Frankfurt a.M., Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aging / metabolism*
Female
Hippocampus / cytology,  metabolism*,  ultrastructure*
Humans
Infant
Lipofuscin / metabolism*
Male
Neurons / metabolism
Vacuoles / metabolism,  ultrastructure
Chemical
Reg. No./Substance:
0/Lipofuscin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Medical care of nursing home residents.
Next Document:  Involvement of histocompatibility and allosensitization in recurrent abortions