Document Detail

Ultrastructural cytochemistry of congenital basophilic leukemia.
MedLine Citation:
PMID:  2438957     Owner:  NLM     Status:  MEDLINE    
A newborn infant was diagnosed as having congenital basophilic leukemia, an extremely rare disorder, by examination of cord blood. An ultrastructural cytochemical study was conducted on the blasts of the infant. Granules of basophil blasts showed ultrastructural characteristics of immature basophil granules and were similar in size to those of normal basophil granules but were fewer in number in each profile. Histochemical studies showed weak reactions for acid mucopolysaccharides and neutral glycoconjugates in the granules, but they were negative for peroxidase. Acid phosphatase was markedly positive. The findings of congenital basophilic leukemia are different from those of basophils in chronic myelocytic leukemia. The patient underwent induction therapy with vincristine and prednisone and has been in complete remission for 21 months.
H Kurosawa; M Eguchi; H Sakakibara; H Takahashi; T Furukawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of pediatric hematology/oncology     Volume:  9     ISSN:  0192-8562     ISO Abbreviation:  Am J Pediatr Hematol Oncol     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7908071     Medline TA:  Am J Pediatr Hematol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
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MeSH Terms
Basophils / ultrastructure
Bone Marrow / ultrastructure
Infant, Newborn
Leukemia / congenital*,  drug therapy,  pathology
Leukemia, Myeloid / pathology
Microscopy, Electron
Prednisone / therapeutic use
Staining and Labeling
Vincristine / therapeutic use
Reg. No./Substance:
53-03-2/Prednisone; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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