| Ultrastructural cytochemistry of congenital basophilic leukemia. | |
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MedLine Citation:
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PMID: 2438957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A newborn infant was diagnosed as having congenital basophilic leukemia, an extremely rare disorder, by examination of cord blood. An ultrastructural cytochemical study was conducted on the blasts of the infant. Granules of basophil blasts showed ultrastructural characteristics of immature basophil granules and were similar in size to those of normal basophil granules but were fewer in number in each profile. Histochemical studies showed weak reactions for acid mucopolysaccharides and neutral glycoconjugates in the granules, but they were negative for peroxidase. Acid phosphatase was markedly positive. The findings of congenital basophilic leukemia are different from those of basophils in chronic myelocytic leukemia. The patient underwent induction therapy with vincristine and prednisone and has been in complete remission for 21 months. |
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Authors:
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H Kurosawa; M Eguchi; H Sakakibara; H Takahashi; T Furukawa |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of pediatric hematology/oncology Volume: 9 ISSN: 0192-8562 ISO Abbreviation: Am J Pediatr Hematol Oncol Publication Date: 1987 |
Date Detail:
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Created Date: 1987-06-26 Completed Date: 1987-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7908071 Medline TA: Am J Pediatr Hematol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 27-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Basophils
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ultrastructure Bone Marrow / ultrastructure Histocytochemistry Humans Infant, Newborn Leukemia / congenital*, drug therapy, pathology Leukemia, Myeloid / pathology Male Microscopy, Electron Prednisone / therapeutic use Staining and Labeling Vincristine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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53-03-2/Prednisone; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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