Document Detail

Ultrastructural comparison of uterine leiomyoma cells from the same myoma nodule before and after gonadotropin-releasing hormone agonist treatment.
MedLine Citation:
PMID:  11163826     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare ultrastructural features of leiomyoma cells from the same uterine myoma nodule before and after GnRH agonist (GnRH-a) treatment and to examine the relation between these ultrastructural changes and the extent of myoma volume reduction with GnRH-a treatment. DESIGN: Prospective clinical study. SETTING: University teaching hospital. PATIENT(S): Twenty women with uterine leiomyomas who were scheduled for surgery. INTERVENTION(S): Transcervical needle biopsy of uterine myoma, s.c. leuprolide acetate injection (3.75 mg) at least three times every 4 weeks before surgery, and hysterectomy or myomectomy. MAIN OUTCOME MEASURE(S): The changes in ultrastructural features of uterine leiomyoma cells and the percentage decrease in the volume of the largest myoma at 12 weeks of GnRH-a treatment measured by magnetic resonance imaging. RESULT(S): A decrease in myofilaments, mitochondrial swelling, and emergence of the lysosomal body were observed in relation to GnRH-a treatment. Furthermore, a positive correlation was observed between the decrease in myofilaments and myoma shrinkage. CONCLUSION(S): Cellular atrophy due to a decrease in myofilaments plays a major role in the reversible myoma shrinkage resulting from GnRH-a treatment.
F Ito; N Kawamura; T Ichimura; A Tsujimura; O Ishiko; S Ogita
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  75     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan.
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MeSH Terms
Antineoplastic Agents, Hormonal / therapeutic use*
Gonadotropin-Releasing Hormone / agonists*
Leiomyoma / drug therapy*,  pathology*,  ultrastructure
Microscopy, Electron
Prospective Studies
Uterine Neoplasms / drug therapy*,  pathology*,  ultrastructure
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 33515-09-2/Gonadotropin-Releasing Hormone

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