Document Detail

Ultrastructural characteristics of distal duodenum mucosa in patients with cirrhosis.
MedLine Citation:
PMID:  11943948     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Morphological abnormalities observed by light microscopy, such as oedema or vasodilatation, have been described in intestinal mucosa of patients with cirrhosis, but no information is available regarding the ultrastructural characteristics of the intestinal epithelial layer. The aim of this observational study was to investigate the ultrastructural characteristics of the intestinal epithelial layer of duodenum mucosa in patients with cirrhosis. METHODS: Six patients with advanced cirrhosis and six control patients without liver disease were included in the study. Biopsies were obtained from the distal duodenum during upper diagnostic endoscopy, and ultrastructural characteristics were studied by means of electron microscopy. RESULTS: A distended interenterocyte space with intestinal epithelial cells closely attached by morphologically intact tight junctions has been observed in cirrhotic patients, together with shorter and wider microvilli than in the control subjects. CONCLUSIONS: The epithelial layers from cirrhotic patients show ultrastructural abnormalities. However, it is not known if the observed alterations are related to the presence of increased intestinal permeability or to bacterial translocation, which are frequently found in these patients.
José Such; José V Guardiola; Joaquín de Juan; Juan A Casellas; Sonia Pascual; José R Aparicio; Javier Solá-Vera; Miguel Pérez-Mateo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  14     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-10     Completed Date:  2002-05-15     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-6     Citation Subset:  IM    
Liver Unit, University General Hospital of Alicante, Miguel Hernández University, 03010 Alicante, Spain.
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MeSH Terms
Duodenum / ultrastructure*
Enterocytes / ultrastructure
Epithelium / ultrastructure
Intestinal Mucosa / ultrastructure*
Liver Cirrhosis / pathology*
Middle Aged
Tight Junctions / ultrastructure
Comment In:
Eur J Gastroenterol Hepatol. 2002 Apr;14(4):351-4   [PMID:  11943944 ]

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