| Ultrastructural changes of oligodendroglia and myelin sheaths induced by ethidium bromide. | |
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MedLine Citation:
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PMID: 431767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracisternal injection of ethidium bromide, an inhibitor of mitochondria associated RNA, DNA and protein synthesis, produced status spongiosus in the subpial surface of the CNS of rats. Ultrastructurally, numerous intra-myelinic vacuoles and prominent degenerative changes of oligodendroglia were observed. The vacuoles were formed between the myelin lamellae by splitting of the intraperiod lines, between the axolemma and the innermost myelin lamellae, and/or between the inner tongue of oligodendroglia and myelin lamellae. In the degenerating oligodendroglia, proliferation and alteration of the endoplasmic reticulum were prominent. In places, altered membranes of the endoplasmic reticulum formed concentrical scroll-like structures. These ultrastructural changes in ethidium bromide treated rats were compared with other similar previously described changes in animals treated with TET, cuprizone, hexachlorophene, hypocholesterolaemic drugs and actinomycin D. |
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Authors:
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K Yajima; K Suzuki |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuropathology and applied neurobiology Volume: 5 ISSN: 0305-1846 ISO Abbreviation: Neuropathol. Appl. Neurobiol. Publication Date: 1979 Jan-Feb |
Date Detail:
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Created Date: 1979-06-11 Completed Date: 1979-06-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7609829 Medline TA: Neuropathol Appl Neurobiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 49-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Diseases / chemically induced* Brain Stem / pathology* Ethidium / toxicity* Male Microscopy, Electron Myelin Sheath / ultrastructure* Neuroglia / ultrastructure* Oligodendroglia / ultrastructure* Rats |
| Chemical | |
Reg. No./Substance:
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3546-21-2/Ethidium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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