Document Detail

Ultrastructural changes in rat adipomusculocutaneous flaps during warm ischaemic storage and reperfusion.
MedLine Citation:
PMID:  8471534     Owner:  NLM     Status:  MEDLINE    
Electron microscopy (EM) was used to evaluate ultrastructural changes in adipomusculocutaneous rat flaps which had been stored for 0, 2, 4, 6 and 8 hours under normothermic conditions (37 degrees C). The effects of treatment with desferrioxamine (DFX) or hypertonic citrate flush (HCA), prior to 4 hours of storage, were compared to untreated flaps which had been stored for 4 hours. Ultrastructural changes caused by 30 minutes of reperfusion, were also studied. Most ultrastructural alterations occurred between 2 and 4 hours of warm storage and there were further changes in some cells after short periods of reperfusion. DFX decreased smooth muscle damage and HCA protected adipocytes but neither of these agents preserved endothelial cells. These studies indicated that free radical-dependent and independent mechanisms were both involved in events which led to flap necrosis after periods of warm storage and reperfusion.
H Nishikawa; P R Fryer; P Sarathchandra; S Manek; A Charlett; C J Green
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of experimental pathology     Volume:  74     ISSN:  0959-9673     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-05-17     Completed Date:  1993-05-17     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  45-53     Citation Subset:  IM    
Department of Plastic Surgical Research, Mount Vernon Hospital, Northwood, Middlesex, UK.
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MeSH Terms
Adipose Tissue / blood supply,  ultrastructure
Endothelium, Vascular / ultrastructure
Epidermis / ultrastructure
Hair / ultrastructure
Ischemia / pathology*
Microscopy, Electron
Muscle, Smooth / ultrastructure
Muscles / blood supply
Rats, Inbred Strains
Reperfusion Injury / pathology*
Skin / blood supply
Surgical Flaps / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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