Document Detail


Ultrastructural changes in primary guinea pig osteoarthritis with special reference to collagen.
MedLine Citation:
PMID:  8703444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Collagen fibril distribution and surface and volume densities in proximal tibial articular cartilage were measured in 6- and 12-month-old Dunkin-Hartley guinea pigs developing primary osteoarthritis. At 12 months, gross fibrillation and ulceration of the articular cartilage were observed on the medial but not on the lateral condyle. Collagen volume density decreased with age in the interterritorial compartments in the superficial zone, medially by 16% and laterally by 8%. In the upper radial zone, collagen volume density decreased interterritorially by 10% on the medial condyle only. Despite gross osteoarthritic changes, only moderate and predominantly focal ultrastructural collagen changes were observed. Thus neither gross network disruption nor fibril thickening seems to be a general feature in early guinea pig osteoarthritis.
Authors:
H Hedlund; E de Bri; S Mengarelli-Widholm; F P Reinholt; O Svensson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  104     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-09-09     Completed Date:  1996-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  374-82     Citation Subset:  IM    
Affiliation:
Division of Orthopedics, Karolinska Institutet, Huddinge Hospital, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cartilage, Articular / chemistry,  ultrastructure*
Collagen / ultrastructure*
Guinea Pigs
Male
Osteoarthritis / metabolism,  pathology*
Tibia / chemistry,  ultrastructure
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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