Document Detail

Ultrastructural changes in the ovaries of Sl/Slt mutant mice, showing developmental deficiency of follicles and tubular adenomas.
MedLine Citation:
PMID:  3800599     Owner:  NLM     Status:  MEDLINE    
Structural changes in the ovaries of WBB6F1-Sl/Slt mutant mice aged 10, 25, 35, and 60 days and 7 months were studied light and electron microscopically. Neither secondary nor Graafian follicles could be found in any of the animals studied, and only primary follicles were usually seen until 35 days. In most follicles, the oocyte was lost. The hyperplastic proliferation of follicle epithelial cells, forming large round or oval cell clusters, occurred in 60-day-old mice. In 7-month-old animals, the ovaries were mostly occupied with invasive peritoneal epithelial tubules and masses of epitheloid cells which are apparently derived from the follicle epithelial cells. Although the ultrastructure of the oocyte and the follicle epithelial cell of the primary follicle is not different from that of +/+ control animals, the lack of gap junctions between the oocytes and the surrounding follicle epithelial cells may cause these abnormalities. The epitheloid cells that appeared in the 60-day-old animals are suggested to produce some steroid hormones, since they have cell organelles characteristic for steroid biosynthesis, such as well-developed smooth endoplasmic reticulum, oval mitochondria with tubulovesicular cristae, and numerous lipid droplets.
K Ishimura; H Matsuda; H Tatsumi; H Fujita; N Terada; Y Kitamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archivum histologicum Japonicum = Nihon soshikigaku kiroku     Volume:  49     ISSN:  0004-0681     ISO Abbreviation:  Arch Histol Jpn     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1987-02-10     Completed Date:  1987-02-10     Revised Date:  2011-07-29    
Medline Journal Info:
Nlm Unique ID:  0146564     Medline TA:  Arch Histol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  379-89     Citation Subset:  IM    
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MeSH Terms
Adenoma / genetics,  veterinary
Aging / genetics*
Mice, Mutant Strains / anatomy & histology*
Microscopy, Electron
Oocytes / ultrastructure
Ovarian Follicle / abnormalities
Ovarian Neoplasms / genetics,  veterinary
Ovary / ultrastructure*
Rodent Diseases / genetics

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