Document Detail

Ultrastructural changes in the mouse fetal choroid plexuses following chronic maternal alcoholization.
MedLine Citation:
PMID:  2530447     Owner:  NLM     Status:  MEDLINE    
Female mice (RAP strain) were alcoholized for 30-50 days before mating and during pregnancy until killing, with a 20% solution of ethanol administered instead of drinking water. From foetuses of 16, 18 and 20 days and from newborn puppies (day 1) choroid plexuses were excised and electronmicroscopically examined. Chronic maternal alcoholization induced the lowering of glycogen content in the choroid cells of 16 day old foetuses, the swelling and vacuolization of mitochondria with the disappearance of cristae and enlargement of the Golgi complex--in the choroid cells at all the developmental stages controlled, the enlargement of intercellular spaces within the choroid epithelium and between the capillaries and the epithelial layer. The changes detected are presumedly due to disturbances of intracerebral fluid homeostasis and may be responsible for at least some of the CNS pathology observed in alcohol embryo- and fetopathy.
C Crăciun; I Checiu; V Crăciun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Morphologie et embryologie     Volume:  35     ISSN:  0377-5038     ISO Abbreviation:  Morphol Embryol (Bucur)     Publication Date:    1989 Jul-Sep
Date Detail:
Created Date:  1989-12-21     Completed Date:  1989-12-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7512183     Medline TA:  Morphol Embryol (Bucur)     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
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MeSH Terms
Alcoholism / pathology*
Choroid Plexus / embryology*,  ultrastructure
Maternal-Fetal Exchange*
Microscopy, Electron

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