Document Detail

Ultrastructural changes in the liver in experimental non-A, non-B hepatitis.
MedLine Citation:
PMID:  6784744     Owner:  NLM     Status:  MEDLINE    
Factor VIII, a blood-clotting derivative prepared from pooled human plasma, previously shown to cause a short-incubation-period non-A, non-B hepatitis in patients and in chimpanzees, was studied further to establish the nature of the pathological lesions associated with this infection. Percutaneous liver biopsy specimens were examined in detail. Cytoplasmic changes in the hepatocytes were observed on the 7th day after inoculation in one instance and after 13 days in the second, and persisted in the biopsy specimens for 13 weeks after infection. Abnormalities in hepatocyte nuclei, including aggregates of irregularly shaped particles 15-20 nm in size, were observed about 1 week after the onset of the cytoplasmic changes. The ultrastructural changes are described and their nature and significance discussed. Attention is drawn to somewhat similar cytoplasmic and nuclear changes occurring in other disease entities.
K N Tsiquaye; S Amini; H Kessler; R G Bird; G Tovey; A J Zuckerman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  62     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-51     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / ultrastructure
Cytoplasm / ultrastructure
Endoplasmic Reticulum / ultrastructure
Hepatitis C / pathology*
Hepatitis, Viral, Human / pathology*
Liver / ultrastructure*
Microscopy, Electron
Pan troglodytes

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