Document Detail

Ultrastructural changes in the ischemic zone bordering experimental infarcts in rat left ventricles.
MedLine Citation:
PMID:  851166     Owner:  NLM     Status:  MEDLINE    
Ultrastructural changes in myocardial cells from the ischemic border of infarcts (produced in rat left ventricles by ligating the anterior coronary artery in vivo) were examined 1 to 24 hours after ligation. Twenty-four hours after ligation, irreversibly injured cells showed a selective spreading of Z-band material over the I band; disappearance of M bands, prominent N bands, and disassembly of A bands were also noteworthy. Sixty minutes after ligation the cells of the ischemic border were ultrastructurally normal except for paradoxically relaxed sarcomeres, indicative of an inability to contract in response to the calcium influx produced by osmium tetroxide; progressive vacuolization of this zone was evident after 4 to 12 hours. Paradoxical relaxation may be an ultrastructural correlate of acute ischemic "pump failure".
E Page; P I Polimeni
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of pathology     Volume:  87     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-05-27     Completed Date:  1977-05-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-104     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Membrane / ultrastructure
Disease Models, Animal*
Mitochondria, Muscle / ultrastructure
Myocardial Infarction / pathology*
Myocardium / ultrastructure*
Myofibrils / ultrastructure
Vacuoles / ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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