| Ultrastructural behavior of human immunodeficiency virus (HIV) in multinucleated giant cells in the brain of a Japanese hemophiliac presenting AIDS encephalopathy. | |
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MedLine Citation:
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PMID: 2763379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human immunodeficiency virus (HIV) was detected ultrastructurally and immunohistochemically in the brain of a Japanese hemophiliac presenting AIDS encephalopathy. The encephalopathy was characterized by the multifocal occurrence of multinucleated giant cells mainly in the subcortical areas. The giant cells were identified immunohistochemically to be macrophages. HIV particles were observed in and out of the giant cells, and most of the particles ingested in the cells were membrane-bound. Some virus particles were found in pinocytic vesicles or phagocytic vacuoles, whereas the others were degradated in the lysosomes of the cells. Budding of HIV particles from the cell surface was also observed, indicating replication of the virus in vivo. These findings suggest ingestion, digestion, and replication of HIV by brain macrophages in AIDS. |
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Authors:
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M Naito; M Jogasaki; K Takahashi; S Matsumi; T Hattori; K Takatsuki |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Ultrastructural pathology Volume: 13 ISSN: 0191-3123 ISO Abbreviation: Ultrastruct Pathol Publication Date: 1989 Jul-Aug |
Date Detail:
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Created Date: 1989-09-12 Completed Date: 1989-09-12 Revised Date: 2009-06-26 |
Medline Journal Info:
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Nlm Unique ID: 8002867 Medline TA: Ultrastruct Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-41 Citation Subset: IM; X |
Affiliation:
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Second Department of Pathology, Kumamoto University Medical School, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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etiology,
microbiology*,
pathology Adult Brain / microbiology*, ultrastructure Brain Diseases / etiology, microbiology*, pathology Cell Membrane / microbiology HIV / isolation & purification* Hemophilia A / complications* Humans Immunohistochemistry Lysosomes / microbiology Macrophages / microbiology*, ultrastructure Male Microscopy, Electron Organelles / microbiology Phagocytosis Vacuoles / microbiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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