Document Detail

Ultrastructural analysis of pulmonary alveolar proteinosis induced by methylnaphthalene in mice.
MedLine Citation:
PMID:  1392517     Owner:  NLM     Status:  MEDLINE    
Pulmonary alveolar proteinosis was induced at a 100% incidence in B6C3F1 female mice by twice weekly painting the back skin with methylnaphthalene for 30 weeks to give a total dose of 7.14 g/kg b.wt. Semithin sections were used for defining areas of type II pneumocyte hyperplasia and hypertrophy and associated proteinosis. Ultrastructurally, alveolar spaces were found to be filled with numerous myelinoid structures resembling the lamellar bodies of type II pneumocytes. Mononucleated giant cells (balloon cells, BC) containing numerous myelinoid structures, lipid droplets and many electron dense amorphous ascicular crystals were closely associated with this extracellular membranous material. Stacks of elastic fibers stained with tannic acid and bundles of collagen fibers were loose and discontinuous in the interstitium of affected areas. The following pathogenesis is hypothesized: type II pneumocytes produce increased amounts of lamellar bodies due to their hyperplasia and hypertrophy and develop to form BC which liberate numerous myelinoid structures on their rupture. Epidermal absorption of methylnaphthalene is an efficient reliable method of induction of this internal disease.
Y Murata; Y Emi; A Denda; Y Konishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  44     ISSN:  0940-2993     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-11-12     Completed Date:  1992-11-12     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Laboratory of Oncological Pathology, Nara Medical College, Japan.
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MeSH Terms
Mice, Inbred Strains
Microscopy, Electron
Pulmonary Alveolar Proteinosis / chemically induced,  pathology*
Reg. No./Substance:
0/Naphthalenes; 90-12-0/1-methylnaphthalene; 91-57-6/2-methylnaphthalene

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