Document Detail

Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean.
MedLine Citation:
PMID:  12448776     Owner:  NLM     Status:  MEDLINE    
No direct evidence that genetically modified (GM) food may represent a possible danger for health has been reported so far; however, the scientific literature in this field is quite poor. Therefore, we investigated the possible effects of a diet containing GM soybean on mouse exocrine pancreas by means of ultrastructural, morphometrical and immunocytochemical analyses. Our observations demonstrate that, although no structural modification occurs in pancreatic acinar cells of mice fed on GM soybean, quantitative changes of some cellular constituents take place in comparison to control animals. In particular, a diet containing significant amount of GM food seems to influence the zymogen synthesis and processing.
Manuela Malatesta; Chiara Caporaloni; Luigia Rossi; Serafina Battistelli; Marco B L Rocchi; Francesco Tonucci; Giancarlo Gazzanelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of anatomy     Volume:  201     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-22     Completed Date:  2003-04-14     Revised Date:  2013-06-12    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  England    
Other Details:
Languages:  eng     Pagination:  409-15     Citation Subset:  IM    
Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Italy.
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MeSH Terms
Cell Nucleus / ultrastructure
Endoplasmic Reticulum, Rough / ultrastructure
Food, Genetically Modified*
Golgi Apparatus / ultrastructure
Image Processing, Computer-Assisted*
Mice, Inbred Strains
Microscopy, Electron
Pancreas / chemistry,  ultrastructure*
Secretory Vesicles / ultrastructure
alpha-Amylases / analysis
Reg. No./Substance:

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