Document Detail

Ultrastructural analysis of the interactions between Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica and human tracheal epithelial cells.
MedLine Citation:
PMID:  15652294     Owner:  NLM     Status:  MEDLINE    
Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are respiratory pathogens that colonize the respiratory tract of their host after adhesion to the respiratory epithelium. Presently, the intracellular fate of these bacteria in human tracheal epithelial cells was compared by use of transmission electron microscopy. The three species, even when cytotoxic, were taken-up by epithelial cells. Although, some intracellular bacteria appeared morphologically intact and survived a few days inside epithelial cells, most of them appeared quickly degraded, phenomenon which was associated with an intense cell metabolic activity. Even cytotoxic Bordetella species is ultimately killed by human epithelial cells.
Pascale Gueirard; Laurence Bassinet; Isabelle Bonne; Marie-Christine Prevost; Nicole Guiso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microbial pathogenesis     Volume:  38     ISSN:  0882-4010     ISO Abbreviation:  Microb. Pathog.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-17     Completed Date:  2005-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606191     Medline TA:  Microb Pathog     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France.
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MeSH Terms
Bacterial Adhesion*
Bordetella bronchiseptica / growth & development,  ultrastructure*
Bordetella parapertussis / physiology,  ultrastructure*
Bordetella pertussis / physiology,  ultrastructure*
Cytoplasm / microbiology,  ultrastructure
Epithelial Cells / microbiology*,  physiology*
Microscopy, Electron, Transmission
Trachea / microbiology*,  ultrastructure

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