| Ultrastructural analysis of the cavernous and dorsal penile nerves in experimental diabetes. | |
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MedLine Citation:
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PMID: 8124433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to investigate whether experimental diabetes determines structural changes in peripheral nerves involved in reflexogenic erection, namely the cavernous and the dorsal nerve of the penis. Myelinated axons were examined in the dorsal nerve of the penis from rats with streptozotocin-induced diabetes (3- and 6-month duration). Morphometric analysis disclosed a significant decrease of myelinated fibre size most likely due to a progressive axonal atrophy. In addition, morphological analysis revealed diffuse accumulation of glycogen within axons, lipid droplets in Schwann cells and pronounced sequestration of axoplasm by adaxonal Schwann cell processes. These signs were particularly prominent in 6-month-diabetic rats. Myelinated and unmyelinated axons of the cavernous nerve were analysed in 6-month-diabetic animals. No substantial ultrastructural abnormalities were found in the cavernous nerves. These results suggest that in experimental diabetes regionally specific structural changes occur in neuronal pathways subserving erectile function. |
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Authors:
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G Italiano; L Petrelli; A Marin; D Guidolin; G Venturin; E S Pescatori; F Aragona; F Pagano; C Triban; A Calabrò |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of impotence research Volume: 5 ISSN: 0955-9930 ISO Abbreviation: Int. J. Impot. Res. Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1994-04-12 Completed Date: 1994-04-12 Revised Date: 2006-07-03 |
Medline Journal Info:
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Nlm Unique ID: 9007383 Medline TA: Int J Impot Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 149-60 Citation Subset: IM |
Affiliation:
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Fidia Research Laboratories, Padua, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Body Weight Diabetes Mellitus, Experimental / pathology* Male Microscopy, Electron Nerve Fibers / ultrastructure Nerve Fibers, Myelinated / ultrastructure Neurons / ultrastructure* Penis / innervation*, ultrastructure Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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