Ultrastructural analysis of the adaptation of articular cartilage to mechanical stimulation. | |
MedLine Citation:
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PMID: 1308876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ultrastructural analysis was conducted on samples of articular cartilage taken from both load-bearing and non-load-bearing areas with the aim of evaluating the morphologic adaptation of the articular cartilage to mechanical stimulation and identifying the mechanisms of interaction of the chondrocyte and the matrix. Through this analysis we were able to better define the adaptation process of the cartilage as well as the modalities of mechanical stress transmission. We believe that the complex formed by the chondrocyte, the pericellular matrix, and the pericellular capsule constitutes the biomechanical unit of the articular cartilage which serves as the sensor and transducer of mechanical stress. The arrangement of the collagen fibers and the proteoglycans which make up the pericellular capsule and membrane around the chondrocyte can be compared, from a mechanical standpoint, to a dynamic structure constructed in order to absorb the load stresses and protect the internal environment. From a biological standpoint, these are comparable to an extracellular-scaffold constructed with the aim of mediating the interaction between the chondrocyte and the territorial and inter-territorial compartments. |
Authors:
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F Greco; N Specchia; F Falciglia; A Toesca; S Nori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian journal of orthopaedics and traumatology Volume: 18 ISSN: 0390-5489 ISO Abbreviation: Ital J Orthop Traumatol Publication Date: 1992 |
Date Detail:
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Created Date: 1993-10-18 Completed Date: 1993-10-18 Revised Date: 2006-12-07 |
Medline Journal Info:
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Nlm Unique ID: 7511480 Medline TA: Ital J Orthop Traumatol Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 311-21 Citation Subset: IM; S |
Affiliation:
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Clinica Ortopedica, Università di Ancona. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Cartilage, Articular / physiology, ultrastructure* Extracellular Matrix / ultrastructure Microscopy, Electron Microscopy, Electron, Scanning Rabbits Stress, Mechanical |
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