Document Detail

Ultrastructural analysis of the adaptation of articular cartilage to mechanical stimulation.
MedLine Citation:
PMID:  1308876     Owner:  NLM     Status:  MEDLINE    
Ultrastructural analysis was conducted on samples of articular cartilage taken from both load-bearing and non-load-bearing areas with the aim of evaluating the morphologic adaptation of the articular cartilage to mechanical stimulation and identifying the mechanisms of interaction of the chondrocyte and the matrix. Through this analysis we were able to better define the adaptation process of the cartilage as well as the modalities of mechanical stress transmission. We believe that the complex formed by the chondrocyte, the pericellular matrix, and the pericellular capsule constitutes the biomechanical unit of the articular cartilage which serves as the sensor and transducer of mechanical stress. The arrangement of the collagen fibers and the proteoglycans which make up the pericellular capsule and membrane around the chondrocyte can be compared, from a mechanical standpoint, to a dynamic structure constructed in order to absorb the load stresses and protect the internal environment. From a biological standpoint, these are comparable to an extracellular-scaffold constructed with the aim of mediating the interaction between the chondrocyte and the territorial and inter-territorial compartments.
F Greco; N Specchia; F Falciglia; A Toesca; S Nori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of orthopaedics and traumatology     Volume:  18     ISSN:  0390-5489     ISO Abbreviation:  Ital J Orthop Traumatol     Publication Date:  1992  
Date Detail:
Created Date:  1993-10-18     Completed Date:  1993-10-18     Revised Date:  2006-12-07    
Medline Journal Info:
Nlm Unique ID:  7511480     Medline TA:  Ital J Orthop Traumatol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  311-21     Citation Subset:  IM; S    
Clinica Ortopedica, Università di Ancona.
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MeSH Terms
Adaptation, Physiological
Cartilage, Articular / physiology,  ultrastructure*
Extracellular Matrix / ultrastructure
Microscopy, Electron
Microscopy, Electron, Scanning
Stress, Mechanical

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