Document Detail

Ultrastructural alterations of the cortical epithelial cells of the irradiated and recovering rat thymus.
MedLine Citation:
PMID:  16276026     Owner:  NLM     Status:  MEDLINE    
To understand the roles of cortical thymic epithelial cells (CTECs) in T-lymphocyte development, we analyzed rat thymi recovering from irradiation (6Gy), at the ultrastructural level. The morphological alterations in the CTECs were most prominent during the third to fifth day of recovery, when proliferating thymocytes were observed in the vicinity of the CTECs. The most striking finding among the alterations in the CTECs after irradiation was a cytoplasmic vacuolization with an increased amount of granular and membranous content. The granular content was observed as loosely aggregated structures or finely dispersed granules and dense bodies. The membranous content appeared in various forms including vesicular, tubular, and irregular membranous structures and myelin figures. The above features are characteristic of the hyperfunctional state of CTECs with increased secretion activities, which suggests their important roles in the repopulation and maturation of the cortical thymocytes during recovery after irradiation.
Yamini Arudchelvan; Nobuko Tokuda; Yasuhiro Adachi; Tomoo Sawada; Tetsuo Fukumoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of histology and cytology     Volume:  68     ISSN:  0914-9465     ISO Abbreviation:  Arch. Histol. Cytol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2006-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806082     Medline TA:  Arch Histol Cytol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Department of Human Science, Yamaguchi University School of Medicine, Ube, Japan.
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MeSH Terms
Cell Proliferation / radiation effects
Epithelial Cells / metabolism,  radiation effects,  ultrastructure*
Microscopy, Electron
Thymus Gland / metabolism,  radiation effects*,  ultrastructure*

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