Document Detail

Ultrastructural abnormalities of liver cells in Reye's syndrome.
MedLine Citation:
PMID:  892794     Owner:  NLM     Status:  MEDLINE    
Electon microscopic observations were made on liver biopsy specimens from nine infants and children diagnosed as having Reye's syndrome by clinical, laboratory, and light microscopic criteria. In addition to excessive fat content, mitochondrial abnormalities were the most frequent abnormal finding in the liver. However, no correlation could be established between the severity of mitochondrial changes and clinical or biochemical data, and two patients with low levels of the first two urea cycle enzymes showed only mild mitochondrial abnormalities. Nonspecific or artifactual factors have been suggested to explain the mitochondrial changes. However, the data of this study suggest that most of the reported mitochondrial abnormalities are not artifacts, and that they can be helpful in the ultrastructural diagnosis of Reye's syndrome.
T C Iancu; W H Mason; H B Neustein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human pathology     Volume:  8     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-31     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Liver / ultrastructure*
Microbodies / ultrastructure
Mitochondria, Liver / ultrastructure*
Mitochondrial Swelling
Reye Syndrome / pathology*
Reg. No./Substance:
0/Lipids; 9005-79-2/Glycogen

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