| Ultrastructural and morphological analyses of the in vitro and in vivo hemostatic effects of Ankaferd Blood Stopper. | |
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MedLine Citation:
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PMID: 19833624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ultrastructural and morphological analyses of a novel hemostatic agent, Ankaferd Blood Stopper (ABS), in comparison to its in vitro and in vivo hemostatic effects were investigated. High-resolution scanning electron microscopy (SEM) images accompanied with morphological analysis after topical application of ABS revealed a very rapid (<1 second) protein network formation within concurrent vital erythroid aggregation covering the classical coagulation cascade. Histopathological examination revealed similar in vivo ABS-induced hemostatic network at the porcine hepatic tissue injury model. Instantaneous control of bleeding was achieved in human surgery-induced dental tissue injury associated with primary and secondary hemostatic abnormalities. Ankaferd Blood Stopper could hold a great premise for clinical management of surgery bleedings as well as immediate cessation of bleeding on external injuries based on upcoming clinical trials. |
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Authors:
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Berat Z Haznedaroglu; Ibrahim C Haznedaroglu; Sharon L Walker; Hasan Bilgili; Hakan Goker; Ali Kosar; Alper Aktas; Ozge Captug; Mevlut Kurt; Oktay Ozdemir; Serafettin Kirazli; Huseyin C Firat |
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Publication Detail:
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Type: Journal Article Date: 2009-10-14 |
Journal Detail:
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Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 16 ISSN: 1938-2723 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 446-53 Citation Subset: IM |
Affiliation:
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Department of Chemical and Environmental Engineering, University of California, Riverside, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Cells / drug effects, ultrastructure Hemorrhage / blood, drug therapy*, pathology Hemostasis / drug effects* Hemostatics / pharmacology* Humans Liver / drug effects, ultrastructure Liver Cirrhosis, Experimental / blood, drug therapy, pathology Microscopy, Electron, Scanning Models, Animal Plant Extracts / pharmacology* Serum / cytology, drug effects Swine |
| Chemical | |
Reg. No./Substance:
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0/Hemostatics; 0/Plant Extracts; 0/ankaferd blood stopper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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