| Ultrasound thrombolysis. | |
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MedLine Citation:
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PMID: 18462769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ultrasound energy for thrombolysis dates back to 1976. Trubestein et al. demonstrated first in vitro that a rigid wire delivery low frequency ultrasound energy could disrupt clot. These investigators also showed that this system had potential for peripheral arterial clot dissolution in vivo in animal studies [G. Trubestein, C. Engel, F. Etzel, Clinical Science 51 (1976) 697s-698s]. Subsequently, four basic approaches to ultrasonic thrombolysis have been pursued--two without pharmacological agents: (1) catheter-delivered external transducer ultrasound, (2) transcutaneous-delivered HIFU external ultrasound without drug delivery and ultrasound in conjunction with thrombolytic drugs and/or microbubbles or other agents, (3) Catheter-delivered transducer-tipped ultrasound with local drug delivery, and (4) transcutaneous-delivered low frequency ultrasound with concomitant systemic (intravenous) drug delivery for site specific ultrasound augmentation. This article reviews recent data on therapeutic ultrasound for thrombolysis in vitro, in vivo, in animal studies, as well as in human clinical trials. |
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Authors:
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Robert J Siegel; Huai Luo |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-03-28 |
Journal Detail:
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Title: Ultrasonics Volume: 48 ISSN: 1874-9968 ISO Abbreviation: Ultrasonics Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-09-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0050452 Medline TA: Ultrasonics Country: Netherlands |
Other Details:
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Languages: eng Pagination: 312-20 Citation Subset: IM |
Affiliation:
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Cedars-Sinai Medical Center, Cardiac Noninvasive Laboratory, David Geffen School of Medicine at UCLA, 8700 Beverly Boulevard, Room 5623, Los Angeles, CA 90048, USA. siegel@cshs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clinical Trials as Topic Coronary Thrombosis / therapy Drug Delivery Systems / instrumentation Equipment Design Equipment Safety Fibrinolytic Agents / administration & dosage Humans Microbubbles Myocardial Infarction / therapy Thrombolytic Therapy / instrumentation* Transducers Ultrasonic Therapy / methods* Vascular Patency |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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