Document Detail

Ultrasound screening for chromosomal anomalies in the first trimester of pregnancy.
MedLine Citation:
PMID:  8372077     Owner:  NLM     Status:  MEDLINE    
For the last 6 years, sonographic signs for excessive fluid accumulation in the backs of 10- to 12-week-old fetuses have been looked for prior to transabdominal chorionic biopsy. In 1400 pregnancies, subsequent karyotype analyses revealed 28 cases of Down syndrome. In 15 (= 54 per cent), a large fluid cushion over most of the back had been documented at the time of biopsy. Only a few chromosomally normal fetuses with the same peculiarity were observed. The cushion was also present in fetuses with trisomies 18 and 13, and in Turner syndrome. Systematic first-trimester screening for nuchal fluid accumulation seems to be a recommended method for the detection of Down syndrome and other chromosome anomalies in young pregnant women at low risk. It compares favourably with current methods of maternal serum screening performed at 16-18 weeks which require a higher number of invasive procedures.
G Savoldelli; F Binkert; J Achermann; W Schmid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  13     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  IM    
Institute of Medical Genetics, University of Zurich, Switzerland.
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MeSH Terms
Chromosome Aberrations / ultrasonography*
Chromosome Disorders
Down Syndrome / ultrasonography
Mass Screening / methods
Neck / ultrasonography*
Pregnancy Trimester, First
Retrospective Studies
Risk Factors
Ultrasonography, Prenatal*

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