| Ultrasound screening for chromosomal anomalies in the first trimester of pregnancy. | |
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MedLine Citation:
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PMID: 8372077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For the last 6 years, sonographic signs for excessive fluid accumulation in the backs of 10- to 12-week-old fetuses have been looked for prior to transabdominal chorionic biopsy. In 1400 pregnancies, subsequent karyotype analyses revealed 28 cases of Down syndrome. In 15 (= 54 per cent), a large fluid cushion over most of the back had been documented at the time of biopsy. Only a few chromosomally normal fetuses with the same peculiarity were observed. The cushion was also present in fetuses with trisomies 18 and 13, and in Turner syndrome. Systematic first-trimester screening for nuchal fluid accumulation seems to be a recommended method for the detection of Down syndrome and other chromosome anomalies in young pregnant women at low risk. It compares favourably with current methods of maternal serum screening performed at 16-18 weeks which require a higher number of invasive procedures. |
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Authors:
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G Savoldelli; F Binkert; J Achermann; W Schmid |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 13 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-10-14 Completed Date: 1993-10-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 513-8 Citation Subset: IM |
Affiliation:
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Institute of Medical Genetics, University of Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations
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ultrasonography* Chromosome Disorders Down Syndrome / ultrasonography Female Humans Mass Screening / methods Neck / ultrasonography* Pregnancy Pregnancy Trimester, First Retrospective Studies Risk Factors Ultrasonography, Prenatal* |
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