Document Detail


Ultrasound prediction of pulmonary hypoplasia in congenital diaphragmatic hernia-correlation with pathology.
MedLine Citation:
PMID:  21520476     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To examine the relationship between observed to expected (o/e) lung-to-head circumference ratio (LHR) and lung-to-body weight ratio (LBWR) in fetuses with congenital diaphragmatic hernia(CDH). PATIENTS AND METHODS: Were included in the study all consecutive fetuses with CDH and termination of pregnancy in whom a postmortem examination was available. Contralateral fetal lung area was measured by 2D-US using the longest axis method and the o/e LHR was calculated based on the appropriate normal mean for gestation. Regression analysis was used to determine the significance of association between the LBWR and the o/e LHR for left and right-sided cases respectively and subsequently the predicted LBWR in left-sided CDH was calculated using the regression equation. Regression analysis was used to investigate the effect on the proportionate difference between the predicted and the observed LBWR of gestational age at o/e LHR, time length between o/e LHR and LBWR measurement, proportionate weight of the ipsilateral vs. total lung weight, presence of associated anomalies and intrathoracic herniation of the liver. RESULTS: There were 23 fetuses with left-sided and 7 fetuses with right-sided CDH. In left-sided CDH, the LBWR and the o/e LHR correlated significantly following the linear equation: LBWR = 0.0134 x o/e LHR (%) + 0.0043 (r = 0.52; p = 0.012) while this was not the case for right-sided CDH: LBWR = -0.0014 x o/e LHR (%) + 0.0107 (r = 0.08; p = 0.862). Regression analysis showed that proportionate difference between the predicted and the observed LBWR was significantly and independently associated with GA at o/e LHR measurement and proportionate weight of ipsilateral vs. total lung weight. CONCLUSION: In left-sided CDH, o/e LHR correlates well with LBWR irrespective of the time length between o/e LHR and LBWR measurement, presence of associated anomalies and intrathoracic herniation of the liver. Inconsistencies between both measurements are mainly attributable to the contribution of the ipsilateral lung to the total lung weight. In right-sided CDH, o/e LHR does not correlate with LBWR. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
Jacques C Jani; Anne-Gaël Cordier; Jéléna Martinovic; Cleisson Fábio Peralta; Marie-Victoire Senat; Valérie Segers; Alexandra Benachi
Related Documents :
1919336 - Glycoconjugates in the human fetal endolymphatic sac as detected by lectins.
6546316 - Comparison of lecithin: sphingomyelin ratio, fluorescence polarization, and phosphatidy...
24356686 - Intimate partner violence and unintended pregnancy: prevalence and associated factors.
17653556 - Relationship between l/t ratio and lhr in the prenatal assessment of pulmonary hypoplas...
6861606 - Effect of propranolol on the acid base balance and hemodynamics of 'chronically instrum...
17097646 - Case of progressive intrauterine twin pregnancy after surgical treatment of cornual pre...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-26
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Fetal Medicine and Treatment Units, Brussels, Belgium. jackjani@hotmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adnexal masses difficult to classify as benign or malignant using subjective assessment of gray scal...
Next Document:  Prenatal Diagnosis of a Pulmonary Arteriovenous Malformation.