| Ultrasound-induced thermal elevation in clotted blood and cranial bone. | |
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MedLine Citation:
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PMID: 17490808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ultrasound thermal effects have been hypothesized to contribute to ultrasound-assisted thrombolysis. To explore the thermal mechanism of ultrasound-enhanced thrombolysis with recombinant tissue plasminogen activator (rt-PA) for the treatment of ischemic stroke, a detailed investigation is needed of the heating produced in skull, brain and blood clots. A theoretical model is developed to provide an estimate for the worst-case scenario of the temperature increase in blood clots and on the surface of cranial bone exposed to 0.12- to 3.5-MHz ultrasound. Thermal elevation was also assessed experimentally in human temporal bone, human clots and porcine clots exposed to 0.12 to 3.5-MHz pulsed ultrasound in vitro with a peak-to-peak pressure of 0.25 MPa and 80% duty cycle. Blood clots exposed to 0.12-MHz pulsed ultrasound exhibited a small temperature increase (0.25 degrees C) and bone exposed to 1.0-MHz pulsed ultrasound exhibited the highest temperature increase (1.0 degrees C). These experimental results were compared with the predicted temperature elevations. |
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Authors:
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Volodymyr Nahirnyak; T Douglas Mast; Christy K Holland |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural Date: 2007-05-09 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 33 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-01 Completed Date: 2007-11-13 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1285-95 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45267-0586, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Combined Modality Therapy Heating Humans Models, Biological Recombinant Proteins / therapeutic use Stroke / therapy* Sus scrofa Temperature Temporal Bone / physiology* Thrombolytic Therapy* Tissue Plasminogen Activator / therapeutic use* Ultrasonic Therapy* |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS047603/NS/NINDS NIH HHS; R01 NS047603-04/NS/NINDS NIH HHS; R01-NS047603/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; EC 3.4.21.68/Tissue Plasminogen Activator |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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