Document Detail

Ultrasound in prenatal diagnosis: polemics around routine ultrasound screening for second trimester fetal malformations.
MedLine Citation:
PMID:  11981909     Owner:  NLM     Status:  MEDLINE    
Ultrasound for routine fetal malformation screening has been polemical from its early beginning because of the very broad range of diagnosis rates disclosed, i.e. from 13% to 82%, average 27.5%. A review of available studies is proposed to assess objectively the efficacy of ultrasound, considering also economical, ethical and methodological aspects as influential factors for choosing a routine screening policy. The utility of fetal malformation diagnosis before birth is brought forward, including second opinion, karyotyping, poly-disciplinary case discussion prior to management. Method and material of reviewed studies considerably vary and might influence the sensitivity results, as the choice of the population sample and selection of pregnant women, gestation age at screening, distribution of malformation among systems or tracts, exclusion of some fetal malformation and the routine practice of autopsy. Efficiency of screening studies is compared, and among them Radius and Eurofetus studies. Average sensitivity is finally considered as satisfactory in the daily practice when operated by trained personnel. The importance of additional factors for successful screening are emphasized such as education, equipment quality and fetal ultrasound examination at different gestation age for a better understanding of natural history of fetal morphology.
Salvator Levi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  22     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-09-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-95     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Ultrasound Laboratory, Obstetrics and Gynecology, University Hospital Brugmann, Brussels, Belgium.
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MeSH Terms
Congenital Abnormalities / ultrasonography*
Cost-Benefit Analysis
Ethics, Medical
False Negative Reactions
False Positive Reactions
Infant, Newborn
Mass Screening / methods
Pregnancy Complications / ultrasonography
Pregnancy Trimester, Second
Reproducibility of Results
Sensitivity and Specificity
Ultrasonography, Prenatal* / economics,  instrumentation,  standards,  utilization

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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